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KMID : 0881720170320060536
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Journal of Food Hygiene and Safety
2017 Volume.32 No. 6 p.536 ~ p.541
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Protective Effect of Litsea japonica Fruit Flesh Extract on Stress-induced Gastritis in Rats
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Park In-Jae
Park Sung-Hwan
Yun Ji-Hyun
Choi Goo-Hee
Kim Hyun-Jung
Seo Yun-Hee
Cho Ju-Hyun
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Abstract
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The object of this study was to investigate the inhibitory effects of Litsea japonica fruit flesh extract (LJF-HE) on gastritis of an stress-induced SD rat model. Rats were randomly divided into six groups: Normal (normal group), Control (stress-induced gastritis), Ranitidine (stress-induced gastritis and ranitidine 50 mg/kg), LJFHE-L (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 30 mg/kg), LJF-HE-M (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 60 mg/kg), LJF-HE-H (stress-induced gastritis pretreated with L. japonica fruit flesh extract at 120 mg/kg). In groups treated with LJF-HE, gastric mucosal damage and pepsin activity were reduced. Additionally, there were decreases in the expression of cholecystokinin 2 receptor (CCK-2r) in the gastric lesions. The plasma levels of IL-1β slightly but significantly decreased in LJF-HE treated groups compared to control. The plasma level of PGE2 was also significantly increased in LJF-HE treated groups. These results suggest that LJF-HE has the ability to reduce of the severity stress-induced gastritis.
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KEYWORD
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Litsea japonica , Gastritis , Stress , Gastric Ulcer
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